David R. Foster, Pharm.D. Associate Professor of Pharmacy Practice, Purdue University Adjunct Assistant Professor of Medicine, Indiana University Phone: (317) 613-2315 x309 Fax: (317) 613-2316 E-mail: drfoster@iupui.edu Full directory listing

Education

Research

Dr. Foster's research interests are focused on the study of alterations in drug and nutrient disposition and drug effects in critically ill patients. Current research includes evaluation of changes in intestinal permeability to xenobiotics in critical illness. Specifically, this research involves the investigation of alterations in drug and nutrient absorption by passive and active transport mechanisms, and the molecular mediators underlying these changes in burn injury and sepsis. A related area of research is the use of natural anti-inflammatory compounds to attenuate inflammation-related changes in intestinal function. Other interests include the study of the contribution of active transport processes to variability in drug disposition in a number of patient populations. Dr. Foster's clinical interests are focused the provision of pharmacotherapy to critically-ill patients, with an emphasis on burn and trauma patients.

Dr. Foster is a member of the American College of Clinical Pharmacy, the Society of Critical Care Medicine, the American Society for Parenteral and Enteral Nutrition, the American Society for Clinical Pharmacology and Therapeutics, the American Association of Colleges of Pharmacy, and the Indiana College of Clinical Pharmacy.

Representative Publications

Foster DR, Gonzales JP, Amidon GL, Welage LS. Intestinal dipeptide absorption is preserved during thermal injury and cytokine treatment. JPEN: Journal of Parenteral and Enteral Nutrition. 2009;33:520-528.

Foster DR, Yee S, Bleske BE, Carver PL, Shea MJ, Menon SS, Ramachandran C, Welage LS, Amidon GL. Lack of interaction between the peptidomimetic substrates captopril and cephradine. Journal of Clinical Pharmacology. 2009;49:360367.

Foster DR, Landowski CP, Zheng X, Amidon GL, Welage LS. Interferon-gamma increases expression of the di/tri-peptide transporter, h-PEPT1, and dipeptide transport in cultured human intestinal monolayers. Pharmacological Research. 2009;59:215-220.

Huang R, Murray DJ, Foster DR. Role of xenobiotic efflux transporters in resistance to vincristine. Biomedicine and Pharmacotherapy. 2008;62:59-64.

Foster DR, Sowinski KM, Chow HHS, Overholser BR. Limited sampling strategies to estimate exposure to the green tea polyphenol, epigallocatechin gallate, in fasting and fed conditions. Therapeutic Drug Monitoring. 2007;29:835-842.

Foster DR, Zheng X. Cephalexin inhibits N-formylated peptide transport and intestinal hyperpermeability in Caco2 cells. Journal of Pharmacy and Pharmaceutical Sciences. 2007;10:330-341.

Huang R, Murry DJ, Kolwankar D, Hall SD, Foster DR. Vincristine transcriptional regulation of efflux drug transporters in carcinoma cell lines. Biochemical Pharmacology. 2006;17:1695-1704.

Neudeck BL, Foster DR, Li L, Gonzales JP, Welage LS. The effects of thermal injury on transcellular permeability and intestinal p-glycoprotein in rats. Burns. 2003;29:803-809.

Landowski CP, Sun D, Foster DR, Menon SS, Ramachandran C, Welage LS, Amidon GL. Gene expression in the human intestine and correlation with oral valacyclovir pharmacokinetic parameters. Journal of Pharmacology and Experimental Therapeutics 2003;306:778-786.

Sun D, Lennernas H, Welage L, Barnett J, Landowski C, Foster DR, Fleisher D, Lee KD, Amidon GL. A Comparison of Human and Caco2 Gene Expression Profiles for 12,000 Genes and the Permeabilities of 26 Drugs in the Human Intestine and Caco-2 Cells. Pharmaceutical Research. 2002;19:1400-1416.