Brian R. Overholser
Post-Doctoral Fellowship, Pharmacokinetics/Pharmacodynamics, Purdue University , 2001-2004.
My research program is focused on the clinical pharmacology of cardiovascular drugs. The overall goal is to enhance the understanding of pathophysiological mechanisms and pharmacological factors influencing the response variability to cardiovascular active agents.
Overholser BR, Zheng X, Pell C, Blickman A. Sudden death in the presence of overt beta-adrenergic receptor activation in guinea pigs immediately following isoflurane anesthesia. Journal of Veterinary Anaesthesia and Analgesia. 2010; 37:273-9.
Overholser BR, Zheng X, Tisdale JE. Paroxysmal beta-adrenergic receptor mediated alterations in ventricular repolarization at rapid heart rates during inhibition of potassium outward rectifier currents. Journal of Cardiovascular Pharmacology. 2009;54:253-62.
Tisdale JE, Overholser BR, Sowinski KM, Wroblewski HA, Amankwa K, Borzak S, Kingery JR, Coram R, Zipes DP, Flockhart DA, Kovacs RJ. Pharmacokinetics of ibutilide in patients with heart failure due to left ventricular systolic dysfunction. Pharmacotherapy 2008;28:1461-70.
Overholser BR, Zheng X, Tisdale JE. Catecholaminergic effects on ventricular repolarization during inhibition of the rapid component of the delayed rectifier potassium current in a perfused heart model. Pharmacotherapy. 2008;28:1315-24.